What is repatha used for

What is Repatha®?1

Repatha® is a medicine that lowers levels of ‘bad’ cholesterol (LDL-C) in the blood.

How does it work?

Your liver helps to take LDL-C out of your blood. The liver then breaks down the LDL-C.2
The liver also makes a protein called PCSK9. PCSK9 regulates the amount of LDL-C your liver mops up. When the liver doesn't take the LDL-C in to break it down, the LDL-C stays in the blood and can build up in your arteries. Over time, this build-up can cause serious health problems.2
Repatha® contains the active substance evolocumab, a monoclonal antibody (a type of specialised protein designed to attach to a target substance in the body). Evolocumab is designed to attach to the PCSK9 protein, bringing down its levels. This means that more cholesterol enters the liver and so helps lower the level of cholesterol in the blood.2

Why you need to take Repatha®1

Repatha® is used in patients who cannot currently control their cholesterol levels with diet and medication.
Repatha® works alongside other medications you might take and lifestyle changes. They all work in different ways to help lower your cholesterol. That’s why you’ll need to keep up with any lifestyle changes you’ve already made, like changing your diet and keep taking medications your doctor has prescribed.
Click on the Play Video button and learn more about cholesterol and how Repatha® works.


  1. Repatha® (evolocumab) Patient Information Leaflet.
  2. Heart UK. PCSK9 Inhibitors. Fact Sheet published 21 June 2018. Available at: https://www.heartuk.org.uk/downloads/factsheets/pcsk9i-factsheet.pdf [Last accessed: May 2021].