How is prolia administered

How is Prolia® given?

The recommended Prolia® dose is one pre filled syringe of 60 mg administered once every 6 months, as a single injection under the skin (subcutaneous).1

Where in the body is the injection given?

The Prolia® injection can be given in the:1

  • Upper part of your thigh.
  • Belly, except for a 5 cm (2 inch) area right around your belly button.
  • Outer area of upper arm (only if someone else is giving you the injection).

Where will I get my injections?

Your doctor or nurse will decide what is best: for you or a carer to inject Prolia®, or for this to be done by a healthcare provider. Please discuss this with your prescribing doctor to identify a convenient Prolia® administration plan. If your doctor has instructed you to give yourself the injection, please see below on this page the step-by-step guide on how to do it and see the injection training video.

How do I self-inject with Prolia® Pre-Filled Syringe
with Automatic Needle Guard (ANG)?

This video is intended to help you feel confident when injecting Prolia®. Unless you have been instructed by your doctor or healthcare provider do not try to give yourself the injection.
Clinical monitoring of calcium levels is recommended before each Prolia® dose. Rarely, patients receiving Prolia® may have low calcium levels in the blood (hypocalcaemia). Symptoms include spasms, twitches, or cramps in your muscles, and/or numbness or tingling in your fingers, toes or around your mouth and/or seizures, confusion, or loss of consciousness.1 If any of these apply to you, tell your doctor immediately.
Prolia® is a single subcutaneous injection given in the thigh, abdomen or upper arm once every six months.2

Click the button below to download the
How to administer a pre-filled syringe with Automatic Needle Guard
video script
Download (PDF)

To see the
"How to administer a Pre-filled Syringe with Automatic Needle Guard (ANG)"
video, please click on the
"Play video" button.
Play video
Please Note: Since the making of this video, the latex special warning has been removed. Prolia does not contain latex.
You can find step by step instructions on how to use the Automatic Needle Guard (ANG) Pre-filled Syringe in the Patient Information leaflet contained within the Prolia® box.

The ANG pre-filled syringe

The ANG pre-filled syringe is used like a conventional syringe. Administer the medication by pushing the plunger all the way down.
After delivering the full injection, a needle guard is automatically activated as you release pressure from the plunger, safely covering the injection needle. The ANG pre-filled syringe is disposed of as you would a conventional syringe.

Before you start

  • Ensure that you have read the Patient Information Leaflet instructions provided with this product before use
  • For a more comfortable injection, leave the pre-filled syringe at room temperature for about 30 minutes before injecting
  • Based upon the Patient Information Leaflet instructions1, select and prepare an appropriate injection site

Click here to download the Step by step guide on how to use the Prolia® pre­-filled
syringe with Automatic Needle Guard (ANG).
Download (PDF) ➔

For Considerations Before Starting Prolia® please click here and for Possible Side Effects please click here.

How to remember the next injection

Mark the injection date on your calendar, phone, and/or Prolia® Passport card to keep a record of the next injection date. You can download the Prolia® Passport card on the More Resources page. Also, each pack of Prolia® contains a reminder card, that can be removed from the carton and used to keep a record of the next injection date.

How often Prolia® is given

You only need a Prolia® injection once every six months.1 Prolia® has been developed as a long-term treatment, so it is recommended that you consult your doctor before your next potential injection due date.

If you forgot to take Prolia®

If a dose of Prolia® is missed, the injection should be administered as soon as possible. Thereafter, injections should be scheduled every 6 months from the date of the last injection.1

Stopping Prolia®

To get the most benefit from your treatment in reducing the risk of fractures, it is important to use Prolia® for as long as your doctor prescribes it for you. Do not stop your treatment without contacting your doctor.1

Treatment monitoring

Your doctor or nurse will assess how you are managing your condition while on treatment at regular intervals, and may order repeat DEXA scans (which measure bone density)3 to see how your bone treatment is working. Osteoporosis is a chronic condition that requires a long term treatment to prevent bone loss and fractures.4,5


  1. Prolia® (denosumab) Patient Information Leaflet
  2. Prolia® (denosumab) Summary of Product Characteristics
  3. Irish Osteoporosis Society. What to Expect during a DXA scan. Available at: [Last accessed: May 2021]
  4. Bone HG, et al. Lancet Diabetes Endocrinol. 2017;5:513–23.
  5. Tsourdi E, et al. Bone. 2017;105:11–7.