How is Prolia® (denosumab) administered?


How is Prolia® given?

Prolia® (denosumab) is a single subcutaneous (under-the-skin) injection given in the thigh, abdomen or upper arm every six months.1
How is Prolia® given

Where in the body is the injection given?

The Prolia® (denosumab) injection is given in the thigh, abdomen or upper arm.1

How do I self-inject with Prolia® Pre-Filled Syringe with Automatic Needle Guard (ANG)?

This video is intended to help you feel confident when injecting Prolia®. Unless you have been instructed by your doctor or healthcare provider do not try to give yourself the injection. Clinical monitoring of calcium levels is recommended before each Prolia® dose. Rarely, patients receiving Prolia® may have low calcium levels in the blood (hypocalcaemia). Symptoms include spasms, twitches, or cramps in your muscles, and/or numbness or tingling in your fingers, toes or around your mouth and/or seizures, confusion, or loss of consciousness. If any of these apply to you, tell your doctor immediately.
Prolia® is a single subcutaneous injection given in the thigh, abdomen or upper arm once every six months.2
To see the "How to administer a Pre-filled Syringe with Automatic Needle Guard (ANG)" video, please click on the button below.

You can find step by step instructions on how to use the Automatic Needle Guard (ANG) Pre-filled Syringe in the Patient Information leaflet contained within the Prolia® box.
The ANG pre-filled syringe
The ANG pre-filled syringe is used like a conventional syringe. Administer the medication by pushing the plunger all the way down. After delivering the full injection, a needle guard is automatically activated as you release pressure from the plunger, safely covering the injection needle. The ANG prefilled syringe is disposed of as you would a conventional syringe.
Before you start
  • Ensure that you have read the patient information leaflet instructions provided with this product before use
  • For a more comfortable injection, leave the pre-filled syringe at room temperature for about 30 minutes before injecting
  • Based upon the patient information leaflet instructions1, select and prepare an appropriate injection site
For Prolia® safety information please click here.

Where will I get my injections?

Your healthcare provider will decide what it is best: for you or a carer to inject Prolia®, or for this to be done by the healthcare provider. Please discuss this with your prescribing doctor to identify a convenient Prolia® administration plan.

How to remember the next injection

Speak to your doctor or nurse about the reminder service, Prolong and how to register to receive your treatment reminder

How often Prolia® is given

You only need a Prolia® (denosumab) injection once every six months.1 Prolia® has been developed as a long-term treatment, so it is recommended that you check with your GP surgery when your next prescription is due.

If you forgot to take Prolia®

If a dose of Prolia® is missed, the injection should be administered as soon as possible. Thereafter, injections should be scheduled every 6 months from the date of the last injection.1

Stopping Prolia®

To get the most benefit from your treatment, it is important to use Prolia® for as long as your doctor prescribes it for you. Please talk to your doctor before you consider stopping the treatment.1

How will I know if my medication is working?

Your healthcare provider will check your Bone Mineral Density (BMD) at appropriate intervals during your treatment. They will then discuss these results with you.


  1. Prolia® (denosumab) Patient Information Leaflet
  2. Prolia® (denosumab) Summary of Product Characteristics