About Prolia® (denosumab)

ABOUT PROLIA® (DENOSUMAB)

Prolia® (denosumab) is used to treat:1
  • Osteoporosis in women after the menopause (postmenopausal) and men who have an increased risk of fracture (broken bones), reducing the risk of spinal, non-spinal and hip fractures.
  • Bone loss that results from a reduction in hormone (testosterone) level caused by surgery or treatment with medicines in patients with prostate cancer.
  • Bone loss that results from long-term treatment with glucocorticoids in patients who have an increased risk of fracture.
Prolia® contains denosumab, a protein (monoclonal antibody) that interferes with the action of another protein, in order to treat bone loss and osteoporosis.1
  • There are cells in your body that remove old bone (osteoclasts), and other cells that rebuild bone (osteoblasts).
  • Normally the process of bone formation and resorption is balanced.
  • After the menopause in women, bone-removing cells cause you to lose bone at a rate that is too fast. This can leave you with thinner, weaker bones and put you at risk for breaking a bone.
  • Men also experience bone loss, which can lead to osteoporosis, but this tends to occur later in life.
  • Bone loss can also occur in patients receiving glucocorticoids.
Prolia® stops the cells that break down bone, allowing the cells that build bone to bring the bone turnover process back into balance.
The treatment effect of Prolia® does wear off if treatment is stopped, so it is very important you continue to get your injection every six months unless your doctor tells you to stop the treatment1
For more information on osteoporosis please visit the Irish Osteoporosis Society website

References

  1. Prolia® (denosumab) Patient Information Leaflet

Why am I being prescribed Prolia®

As we get older, our risk of bone breaks and fractures increases. Osteoporosis causes your bones to become brittle and more fragile and falls can become more common. Lifestyle changes and keeping active can help to prevent falling. Food supplements, such as calcium and vitamin D, and drug treatments, such as Prolia®, can strengthen bones which can reduce your risk of a fracture.
Prolia® is used to help improve bone strength and help reduce the risk of fractures in women with osteoporosis after the menopause. You may not see any changes or feel any different in yourself when you are taking it, but Prolia® can reduce your risk of fractures.1
Treatment with Prolia® increases bone mass and can be beneficial in men with osteoporosis who are at high risk of fracture and in prostate cancer patients who have suffered bone loss due to testosterone level reduction caused by surgery or treatment with medicines. Also, treatment with Prolia® can be benefical in patients with bone loss that results from long-term treatment with glucocorticoids in patients who have an increased risk of fracture.1
Your doctor will have considered your medical history and circumstances, as well as information available before deciding to prescribe Prolia®. This might have included clinical trials demonstrating:1
  • The ability of Prolia® to reduce bone loss and gradually restore bone mass
  • The ability of Prolia® to reduce the risk of fracture
  • The side effect profile of Prolia®

References

  1. Prolia® (denosumab) Summary of Product Characteristics.

This site is intended for patients in Ireland who are being treated with an Amgen® product and for Irish Healthcare Professionals (HCPs).

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IE-CBU-0820-00002 August 2020